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Core Compounds Liposomal NAD+ Advanced Formula bottle, 60 capsules.

Third-party tested, made in the USA

Liposomal NAD+, made properly.

Ten researched compounds, two capsules a day. Third-party tested and made in a GMP-certified facility in the USA.

Rated
4.77out of 5, 35 verified reviews
From
$43.74Free US shipping on orders $44+
Formula
10compounds, 2 capsules

Which one

NAD+ is the molecule. NMN is the route to it.

Both formulas act on the same pathway. They enter it at different points, and either one stands on its own.

Liposomal NAD+ bottle

Liposomal NAD+

The coenzyme itself, carried in a phospholipid shell.

Form
Liposomal NAD+ with 9 supporting compounds
Serving
2 capsules daily
Bottle
60 capsules · 30 days
Rated
4.77 from 35 verified reviews

From $43.74$64.99

Single bottle, bought once. Bundle and subscription pricing is on the product page.

View NAD+
NMN Ultimate 10-in-1 bottle

NMN Ultimate 10-in-1

The precursor, so your cells build NAD+ at their own rate.

Form
500 mg NMN with 9 supporting compounds
Serving
2 capsules daily
Bottle
120 capsules · 60 days
Availability
Pre-order - ships when the current batch lands, refundable before it does

From $43.74$64.99

Single bottle, bought once. Bundle pricing is on the product page.

View NMN

Same two-capsule serving and the same third-party testing on both.

Cutaway view of a mitochondrion against a charcoal ground, the outer membrane opened to show the folded inner membrane, the cristae, rim-lit in ivory and teal.
Protons collected in the intermembrane space pass through a channel in the a-subunit, turn the c-ring and the central stalk, and the turning stalk drives the three catalytic sites in the head, which sits in the matrix, to bind ADP and phosphate and release ATP. ADP Pi ATP Intermembrane space protons collect here Matrix where the head sits Inner membrane Outside Matrix c-ring · the rotor the rotor a-subunit two half-channels, separated by a seal peripheral stalk holds the head still head · three catalytic sites three catalytic sites seen from the matrix: the stalk turns counterclockwise
NAD+ picks up two electrons and a proton from the breakdown of food and becomes NADH. NADH carries them to Complex I in the inner mitochondrial membrane, hands the electrons on, and returns to NAD+. The energy released is used by Complex I to push protons out of the matrix. No ATP is made in this loop. Complex I Breaking down food glycolysis and the citric acid cycle electrons come off here NAD+ H electrons from food Q Intermembrane space Outside Matrix Matrix carries them across returns empty, ready again ATP synthase runs on this gradient NAD+ never becomes ATP. It delivers electrons; the energy from those electrons pushes the protons that ATP synthase uses.
In the salvage pathway, NAMPT makes NMN from nicotinamide. The enzyme NMNAT then joins NMN to an ATP molecule, with magnesium, releasing NAD+ and pyrophosphate. The step consumes an ATP rather than producing one. NAM + PRPP NAMPT the rate-limiting step NMN Mg NMNAT nicotinamide-nucleotide adenylyltransferase NMNAT1 nuclear · NMNAT2 cytosolic · NMNAT3 mitochondrial NMN ATP NAD+ PPi One enzyme, one step. The cell spends an ATP to make each NAD+ this way; the step does not produce one.

Inside the cell

The energy behind your everyday.

Explore how your cells make ATP—and where NAD+ and NMN fit.

ATP is assembled by a motor

Protons pushed out of the mitochondrion flow back in through a single channel, and that flow turns a rotor. The turning rotor works three catalytic sites in the head, each of which binds ADP and a phosphate, then lets go of a finished ATP.

  1. Protons gather outside
  2. They return through the channel
  3. The rotor turns
  4. ADP and phosphate bind
  5. ATP is released

Eight protons turn the rotor once around. One turn releases three ATP.

NAD+ carries the electrons

Breaking down food strips electrons out of it, and NAD+ is the molecule that catches them, becoming NADH. It carries them to the membrane, hands them over, and returns to being NAD+, ready for the next pair.

  1. NAD+ collects a pair of electrons
  2. It travels as NADH
  3. Complex I takes the electrons
  4. Protons are pushed out
  5. NAD+ returns

The same molecules go round continuously, which is why a cell holds a pool of NAD+ rather than using it up once.

NMN is one enzyme away from NAD+

Cells rebuild NAD+ continuously through what biologists call the salvage pathway. NMN is the last intermediate on that route: the enzyme NMNAT joins it to an ATP molecule and releases NAD+.

  1. NMN arrives
  2. An ATP joins it
  3. The enzyme closes
  4. NAD+ is released
  5. Pyrophosphate is left over

A precursor is a starting material, not a dose. This is the chemistry, not a claim about what a capsule does in a person.

How our formulas relate

The three views above describe established cell biology. What a supplement does in a person is a separate and much less settled question; the sources below say what is actually known.

Where this comes from

The mechanisms shown above are textbook cell biology:

  • ATP synthase, proton path, rotor and the binding-change mechanism: Fundamentals of Biochemistry, Oxidative Phosphorylation - bio.libretexts.org
  • NAD+ metabolism and the salvage pathway: Covarrubias, Perrone, Grozio and Verdin (2021), NAD+ metabolism and its roles in cellular processes during ageing, Nature Reviews Molecular Cell Biology - nature.com
  • NAMPT as the rate-limiting step, and NMN as the precursor: Garten et al., Nampt: linking NAD biology, metabolism and cancer - PubMed Central. The NMNAT reaction is EC 2.7.7.1: ATP plus NMN gives NAD+ plus diphosphate.

On the supplements themselves, rather than the biology: a 2025 review in Nature Metabolism found the human trial evidence for NAD+ precursors limited, the data on human tissue sparse, and even the claim that NAD+ declines with age less consistent in people than in rodents - nature.com. We have not run absorption or outcome studies on these formulas. If we do, we will publish them.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Talk to your healthcare professional before use if you are pregnant, nursing, taking medication, or have a medical condition.

Reviews

Rated 4.88 out of 5.

Thirty-four verified reviews, collected through Judge.me. The whole distribution is here, including the three that were not five stars.

4.88 out of 5

Reviews of Liposomal NAD+. Individual results vary.

  • 5 star 31
  • 4 star 2
  • 3 star 1
  • 2 star 0
  • 1 star 0

Fits my morning routine

It fits easily into my morning routine and I feel more active during the day. No jitters or crashes, which I really like.

Robert Verified review via Judge.me

Noticeable over time

I’ve been using it for a few weeks now and my energy feels more consistent. Not a huge change overnight, but definitely noticeable over time.

Samantha Verified review via Judge.me

Enough to keep going

I’ve noticed enough improvement to keep using it. That says a lot.

Linda Verified review via Judge.me

Quoted verbatim from Judge.me and attributed exactly as Judge.me attributes them. Nothing is edited, merged or invented.

Before you decide

How do I take it?

Two capsules daily with water, preferably with a meal. A NAD+ bottle is 60 capsules, a 30-day supply. An NMN bottle is 120 capsules, a 60-day supply.

How long before I notice anything?

People respond differently, and we haven’t run a trial on these products, so we can’t give you a timeline. The 30-day money-back guarantee is there so that finding out costs you nothing.

When does NMN ship?

NMN is on pre-order. Your order is confirmed now and ships when the current batch lands, with tracking emailed at dispatch. Change your mind before it ships and we’ll refund you in full.

Are there side effects?

These supplements are generally well tolerated. If you have a medical condition, are pregnant or nursing, or take medication, check with your healthcare professional first.

Where are they made?

In the United States, in GMP-certified facilities, and third-party tested for purity.

Is this a medication?

No. It is a dietary supplement. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Ready when you are

Pick the one that fits.

NAD+ is the coenzyme itself. NMN is the precursor your body converts into it. Two capsules a day either way, third-party tested, made in a GMP-certified facility in the USA.

  • Free US shipping on orders $44+
  • 30-day money-back guarantee
  • NMN is on pre-order and ships when the current batch lands

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.